Tutorials Home

British Hypertension Guidelines Update 1999.

Author: Francisco Machado

Date: 4/11/99

This tutorial is based on a lunchtime presentation at Abersychan Surgery abd should be read in conjuction with the recent BHS guidelines published in the BMJ

To read this document on-line click on the link below.

British Hypertension Society guidelines for hypertension management 1999: summary BMJ 1999;319:630-635 ( 4 September )

Who wrote the guidelines?

Not a single PHCT professional amongst authors in BMJ article!!

How can these guidelines help us manage patients with hypertension?

Questions I asked when looking at the guidelines

  1. How often should patients have their BP measured?
  2. How should I measure BP?
  3. When should I use ambulatory BP monitoring?
  4. How should I assess a patient with hypertension:
    - history
    - examination
    - Investigations
  5. What non-pharmacological measures are effective?
  6. When should I treat?
  7. Which drug should I use?
  8. How should I use these drugs?
  9. Are there any special groups?
  10. When should I refer?
  11. What about statins and aspirin?
  12. How should patients be followed up?
  13. What about a protocol?

 

1. How often should patients have their BP measured?

2. How should I measure BP?

Where do the errors occur?

The patient The Health Professional The equipment
  • Anxiety
  • Obesity
  • Full bladder
  • Cold room
  • Talking
  • Morning v afternoon
  • Inadequate training
  • Observer bias
  • Terminal digit error
  • Calibration
  • Cuffs

BHS recommendations for BP measurement

3. When should I use ambulatory BP monitoring?

4. How should I assess a patient with hypertension?

History tasks

Secondary causes of hypertension
  • Renal causes (90%)
    –diabetic nephropathy
    –chronic pyelonephritis
    –obstructive uropathy
    –glomerulonephritis
    –renal artery stenosis
    -polycystic kidneys
  • Coarctation of aorta
  • Phaeochromocytoma
  • Conn’s syndrome
  • Cushing’s disease
Lifestyle and risk factors for vascular disease
  • Smoking
  • Alcohol consumption
  • Known vascular disease and diabetes
  • Obesity and sedentary lifestyle
  • Salt consumption and hyperlipidaemia
Iatrogenic causes
  • Sympathomimetic amines in cold remedies
  • NSAIDs
  • Oral contraceptives
  • HRT

 

ICE

Not mentioned in the guidelines but it is very important to elicit the patients

Ideas
Concerns
Expectations

With regard to hypertension and its management.

 

Examination

Examine for target organ damage

Cardiac

  • Left ventricular hypertrophy
  • Heart failure

Cerebral

  • CVA or TIA

Peripheral vascular disease

  • Aortic aneurysm and peripheral pulses

Optic

  • Retinopathy

Renal

  • Proteinuria
Examine for secondary causes

 

Cardiovascular

Abdominal examination

General Condition of patient

 

 

Investigation of patients
  • Urinalysis for blood, protein and glycosuria
  • Serum U/E and creatinine, FBC, glucose, cholesterol
  • ECG and CXR

In some

  • Urine for catecholamines
  • US of kidneys
Management

Non pharmacological measures

May result in the patient not requiring treatment or a reduction in the dose and number of agents used

  • Weight reduction
  • Reduced fat and total calorie intake
  • Regular physical exercise
  • Alcohol consumption limited to < 21 in Males and <14 in females
  • Reduction in salt intake

Other lifestyle measures to reduce risk of atherosclerosis

  • Smoking cessation
  • Substitute polyunsaturated fats for saturated fats
  • Increase oily fish diet

5. What non-pharmacological measures are effective?

 

Management

Non pharmacological measures

May result in the patient not requiring treatment or a reduction in the dose and number of agents used

  • Weight reduction
  • Reduced fat and total calorie intake
  • Regular physical exercise
  • Alcohol consumption limited to < 21 in Males and <14 in females
  • Reduction in salt intake

Other lifestyle measures to reduce risk of atherosclerosis

  • Smoking cessation
  • Substitute polyunsaturated fats for saturated fats
  • Increase oily fish diet

6. When should I treat and what target levels should I aim for?

For initial blood pressure flow chart click here.

Targets for Blood Pressure.

 

Measured in Clinic

Mean daytime ambulatory measurement or home measurement

Blood pressure

No Diabetes

Diabetes

No diabetes

Diabetes

Optimal

<140/85

<140/80

<130/80

<130/75

Audit standard

<150/90

<140/85

<140/85

<140/80

7.Which drug should I use?

Which drugs to use first?

Class of drug

Indication

Contraindications

Compelling Possible Possible Compelling
Alpha blockers Prostatism Dyslipidaemia Postural hypotension Urinary Incontinence
ACE inhibitors Heart Failure

LV dysfunction

Type 1 diabetic nephropathy

Chronic renal disease

Type II diabetic nephropathy

Renal impairment

Peripheral vascular disease

Pregnancy

Renovascular disease

Angiotensin II receptor antagonists Cough induced by ACEI Heart failure
Intolerance of other antihypertensive drugs
Peripheral vascular disease Pregnancy

Renovascular disease

Beta blockers Myocardial infarction
Angina
??Heart failure ??Heart failure

Dyslipidaemia

Peripheral vascular disease

Asthma or COPD

Heart block

Calcium antagonists
(dihydropyridine)
Isolated systolic hypertension in elderly Angina

Elderly

   
Calcium antagonists
(rate limiting)
Angina Myocardial infarction Combination with beta blocker Heart block

Heart Failure

Thiazides Elderly   Dyslipidaemia Gout

8.How should I use these drugs?

Rational combinations

beta -blockers and diuretics
ACEI and diuretics
beta -blockers and Calcium antagonists
Calcium antagonists and ACEI's

Cambridge AB/CD rule for optimisation of antihypertensive treatment

Age

Young

Old

Renin levels

High

Low

Absolute risk reduction

Low

High

Relative risk reduction

High

Low

Step 1 mono-therapy

A or B

C or D

Step 2 mono-therapy

C or D

A or B

Step 3 combination

A or B + C or D

A or B + C or D

Resistant hypertension/Intolerance

Add/substitute alpha blocker

Add/substitute alpha blocker

A = ACEI, B = beta-blocker, C = Calcium antagonist, D = Diuretic

Dickerson JEC, Hingorani AD, Ashley MJ et al. Optimisation of antihypertensive treatment by crossover rotation of four major classes. Lancet 1999; 353: 2008-13

9. Are there any special groups?

Elderly
>50% of all people > 60 ð >160/90

More to gain from treatment

Evidence to 80years of age

Diabetics

Pregnancy

10.When should I refer?

11. What about statins and aspirin?

Primary prevention 75mg aspirin is recommended for hypertensive patients aged > 50 who have satisfactory control of BP and either target organ damage, diabetes or a 10 year coronary risk > 15

For primary prevention, statin therapy is indicated up to the age of 70 when serum total CE > 5.0 mmol/l and the 10 year coronary heart disease risk is > 30

For secondary prevention of coronary heart disease statin therapy is indicated up to 75 years if total CE is > 5.0mmol/l and aspirin is indicated (75mg)

12. How should patients be followed up?

Routine

3/12

13. What about a protocol?


Top Tutorials Home

14/11/99 Francisco Machado